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Acronyms listed below
U.S. Human Genome Project
and Related Projects
See also NIH National Human Genome Research Institute (NHGRI)
- On June 13, 2013, The U.S. Supreme Court ruled that naturally occuring DNA cannot be patented, but that synthetically created cDNA is patent-eligbile. The Court heard arguments in the case of Association for Molecular Pathology v. Myriad Genetics, Inc. on April 15, 2013.
- Battelle and United for Medical Research issue, "The Impact of Genomics on the U.S. Economy," an update to Battelle's 2011 industry report. June 13, 2013.
- On June 3, 2013, the U.S. Supreme Court ruled 5-4 in favor of a Maryland law that allows warrantless collection of DNA from persons who have been arrested (Maryland v King) See also argument transcript. Read a summary account at NPR.
- Over 70 leading health care, research, and disease advocacy organizations in more than 40 countries begin steps to form a global alliance for genetic health dedicated to enabling the secure sharing of genomic and clinical data in a standardized (technical and regulatory), effective, and responsible manner. More information is available at the Broad Institute, including a June 3, 2013, White Paper.
- Smithsonian opens human genome exhibit: Unlocking Life's Code. June 2013.
- April 15: Gene patenting case reaches Supreme Court: The U.S. Supreme Court heard arguments in the case of Association for Molecular Pathology v. Myriad Genetics, Inc. A ruling is pending. [See also June 2013 entry above, "The U.S. Supreme Court ruled that naturally occuring DNA cannot be patented]
- HGP marks 10th anniversary NYT: 4/15/2013.
- ENCODE Project results published in Nature, Science and other journals.
The results of the ENCODE project were published in a coordinated set of 30 papers published in multiple journals.
These publications are the result of cross-consortium integrative analysis, covering more than 4
million regulatory regions in the human genome mapped as part of ENCODE. The coordinated publication
set includes one main integrative paper and five other papers in the journal Nature; 18 papers in
Genome Research; and six papers in Genome Biology. The ENCODE data are so complex that the three
journals have developed a pioneering way to present the information in an integrated form they term
"threads." Since the same topics were addressed in different ways in different papers, the
Nature ENCODE website
was developed to allow readers to follow a topic through
all of the papers in the ENCODE publication set. In addition to these publications, six review
articles are being published in the Journal of Biological Chemistry, and other affiliated papers in
Science, Cell, and other journals. The new
Integrative Analysis page on the UCSC ENCODE portal provides links and descriptive material for these publications and related analysis resources. [News Credit: USCS Encode portal.] September, 2012.
- Illumina Launches MyGenome App for iPad; "First Tool of Its Kind for Visualizing the Human Genome", June, 2012.
Chromosome 16 Completed, December 2004.
- Landmark Paper: Finishing
the euchromatic sequence of the human genome, Nature,
Oct. 21, 2004
- Human Gene Count Estimates Changed to
20,000 to 25,000, October 2004.
Chromosome 5 Completed, September 2004.
- Landmark Paper: Human
genome: Quality assessment of the human genome sequence. Nature
429, 365-368 (27 May 2004)
Chromosome 9 Completed, May 2004.
Chromosome 10 Completed, May 2004.
Chromosome 18 Completed, March 2004.
- Human Chromosome 19 Completed,
Chromosome 13 Completed, March 2004.
Chromosome 20 Finished - Chromosome 20 is the third chromosome completely
sequenced to the high quality specified by the Human Genome Project.
- Publication of Initial Working Draft Sequence February
Special issues of Science (Feb. 16, 2001) and Nature (Feb.
15, 2001) contain the working draft of the human genome sequence. Nature
papers include initial analysis of the descriptions of the sequence
generated by the publicly sponsored Human Genome Project, while Science
publications focus on the draft sequence reported by the private company,
Celera Genomics. A press conference was held at 10 a.m., Monday, February
12, 2001, to discuss the landmark publications. Links for more information
Genome Project and the Private Sector: A Working Partnership
Webcast of HGP Press Conference
(Mon. Feb. 12, 2001)
releases on First Analysis of Genome Sequence
de Jong's team (now at the Oakland Children's Hospital, Oakland, CA)
was a major provider of the BAC
libraries used in the sequencing of the human and several other
- HGP leaders and President Clinton announce
the completion of a "working draft" DNA sequence of the human genome.
- Press briefing and remarks
Interview with Ari Patrinos, Director U.S. DOE Human Genome Program
Venter (head of Celera Genomics), Ari Patrinos (director of DOE
Genome Program and Biological and Environmental Research Program),
and Francis Collins (director, NIH National Human Genome Research
- International research consortium publishes chromosome
21 genome, the smallest human chromosome and the second to be completely
- DOE researchers announce completion of chromosomes
5, 16, and 19 draft sequence.
- International collaborators publish genome of fruit fly Drosophila
- President Clinton signs executive order prohibiting federal departments
and agencies from using genetic information in hiring or promoting workers.
- International IMAGE
Consortium established to coordinate efficient mapping and sequencing
of gene-representing cDNAs.
- The Scientist 13:17, Feb. 15, 1999 Hot
Papers In Genomics:
G. Lennon, C. Auffray, M. Polymeropoulos, M.B. Soares, "The I.M.A.G.E.
Consortium: An Integrated Molecular Analysis of Genomes and Their
Expression," Genomics, 33:1512, 1996. (Cited in more than 290 papers
- DOE-NIH ELSI Working Group's Task Force on Genetic and Insurance Information
and NIH revise 5-year goals [Science 262, 43-46 (Oct.
- French Généthon provides mega-YACs to the genome community.
releases U.S. HGP-funded report, "Assessing Genetic Risks."
- LBNL implements novel transposon-mediated chromosome-sequencing system.
- GRAIL sequence-interpretation
service provides Internet access at ORNL.
- Low-resolution genetic linkage map of entire human genome published.
for data release and resource sharing announced by DOE and NIH.
- Human chromosome mapping data repository, GDB,
- Reports by congressional OTA and NAS NRC committees recommend concerted
genome research program.
- HUGO founded by scientists
to coordinate efforts internationally.
- First annual Cold Spring Harbor Laboratory meeting on human genome
mapping and sequencing.
and NIH sign MOU outlining plans for cooperation on genome research.
- Telomere (chromosome end) sequence having implications for aging and
cancer research is identified at LANL.
- Congressionally chartered DOE advisory committee, HERAC,
recommends a 15-year, multidisciplinary, scientific, and technological
undertaking to map and sequence the human genome. DOE designates multidisciplinary
human genome centers.
- NIH NIGMS begins funding of genome projects.
- Robert Sinsheimer holds meeting on human genome sequencing at University
of California, Santa Cruz.
DeLisi and David
A. Smith commission the first Santa Fe conference to assess the
feasibility of a Human Genome Initiative.
- DOE OHER and ICPEMC cosponsor Alta, Utah, conference
highlighting the growing role of recombinant DNA technologies. OTA incorporates
Alta proceedings into report acknowledging value of human genome reference
- LANL and LLNL begin production of DNA clone (cosmid) libraries representing
1977 Project-Enabling Legislation
- The DOE Organization Act of 1977 (P.L. 95-91) mandated the Department "to assure incorporation of national environmental protection goals in the formulation and implementation of energy programs; and to advance the goal of restoring, protecting, and enhancing environmental quality, and assuring public health and safety," and to conduct "a comprehensive program of research and development on the environmental effects of energy technology and program."
1974 Project-Enabling Legislation
- The Federal Non-nuclear Energy Research and Development Act of 1974 (P.L. 93-577) authorized ERDA to conduct a comprehensive non-nuclear energy research, development, and demonstration program to include the environmental and social consequences of the various technologies.
- The Energy Reorganization Act of 1974 (P.L. 93-438) provided that responsibilities of the Energy Research and Development Administration (ERDA) shall include "engaging in and supporting environmental, biomedical, physical, and safety research related to the development of energy resources and utilization technologies."
1946 Project-Enabling Legislation
- The Atomic Energy Act of 1946 (P.L. 79-585) provided the initial charter for a comprehensive program of research and development related to the utilization of fissionable and radioactive materials for medical, biological, and health purposes.
The Atomic Energy Act of 1954 (P.L. 83-706) further authorized the AEC "to conduct research on the biologic effects of ionizing radiation."
- ADA - Americans with Disabilities Act
- ANL - Argonne National Laboratory, a Department of Energy Laboratory
- BAC - bacterial artificial chromosome
- cDNA - complementary deoxyribonucleic acid
- DHHS - Department of Health and Human Services at National Institutes
of Health (NIH)
- DNA - deoxyribonucleic acid
- DOE - Department of Energy
- EEOC - Equal Employment Opportunity Commission
- ELSI - ethical, legal, and social issues
- FY - federal fiscal year (October 1 to September 30)
- GDB - Genome Database
- GRAIL - Gene Recognition and Analysis Internet Link
- HERAC - Health and Enviornmental Research Advisory Committee
- HGI - Human Genome Initiative
- HGP - Human Genome Project, Human Genome Program
- HUGO - Human Genome Organisation
- ICPEMC - International Commission for Protection Against Environmental
Mutagens and Carcinogens
- IMAGE - Integrated Molecular Analysis of Gene Expression
- IOM - Institute of Medicine
- JGI - the Department of Energy's Joint Genome Institute in Walnut
Creek, California. The JGI houses the DOE's production sequencing facility.
- LANL - Los Alamos National Laboratory, a Department of Energy Laboratory
- LBNL - Lawrence Berkeley National Laboratory, a Department of Energy
- LLNL - Lawrence Livermore National Laboratory, a Department of Energy
- MGP - Microbial Genome Project
- MOU - memorandum of understanding
- mRNA - messenger ribonucleic acid
- NAS - National Academy of Sciences
- NCHGR - National Center for Human Genome Research at National Institutes
of Health (NIH)
- NHGRI - National Human Genome Research Institute at National Institutes
of Health (NIH)
- NIGMS - National Institute of General Medical Sciences at National
Institutes of Health (NIH)
- NIH - National Institutes of Health
- NRC - National Research Council
- OBER - Office of Biological and Environmental Research, U.S. Department
of Energy (formerly Office of Health and Environmental Research)
- OHER - Office of Health and Environmental Research, U.S. Department
of Energy (now Office of Biological and Environmental Research)
- ORNL - Oak Ridge National Laboratory, a Department of Energy Laboratory
- OTA - Office of Technology Assessment
- R&D - research and development
- SBH - Sequencing by hybridization
- STS - sequence tagged site
- UNESCO - United Nations Educational, Scientific, and Cultural Organization
- YAC - yeast artificial chromosome
Last modified: Friday, June 14, 2013
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